Modulation of the Gut Microbiota Alters the Tumour-Suppressive Efficacy of Tim-3 Pathway Blockade in a Bacterial Species- and Host Factor-Dependent Manner

T cell immunoglobulin and mucin domain-containing protein-3 (Tim-3) is an immune checkpoint molecule and a target for anti-cancer therapy. In this study, we examined whether gut microbiota manipulation altered the anti-tumour efficacy of Tim-3 blockade. The gut microbiota of mice was manipulated thr...

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Detalles Bibliográficos
Autores principales: Lee, Bokyoung, Lee, Jieun, Woo, Min-Yeong, Lee, Mi Jin, Shin, Ho-Joon, Kim, Kyongmin, Park, Sun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7564046/
https://www.ncbi.nlm.nih.gov/pubmed/32932843
http://dx.doi.org/10.3390/microorganisms8091395

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7564046/
https://www.ncbi.nlm.nih.gov/pubmed/32932843
http://dx.doi.org/10.3390/microorganisms8091395

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