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Functional Analysis of P450 Monooxygenase SrrO in the Biosynthesis of Butenolide-Type Signaling Molecules in Streptomyces rochei

Streptomyces rochei 7434AN4 produces two structurally unrelated polyketide antibiotics lankacidin and lankamycin, and their biosynthesis is tightly controlled by butenolide-type signaling molecules SRB1 and SRB2. SRBs are synthesized by SRB synthase SrrX, and induce lankacidin and lankamycin product...

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Detalles Bibliográficos
Autores principales: Teshima, Aiko, Hadae, Nozomi, Tsuda, Naoto, Arakawa, Kenji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7564063/
https://www.ncbi.nlm.nih.gov/pubmed/32854353
http://dx.doi.org/10.3390/biom10091237