Influenza A M2 Inhibitor Binding Understood through Mechanisms of Excess Proton Stabilization and Channel Dynamics

[Image: see text] Prevalent resistance to inhibitors that target the influenza A M2 proton channel has necessitated a continued drug design effort, supported by a sustained study of the mechanism of channel function and inhibition. Recent high-resolution X-ray crystal structures present the first op...

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Detalles Bibliográficos
Autores principales: Watkins, Laura C., DeGrado, William F., Voth, Gregory A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2020
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7564090/
https://www.ncbi.nlm.nih.gov/pubmed/32933245
http://dx.doi.org/10.1021/jacs.0c06419

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7564090/
https://www.ncbi.nlm.nih.gov/pubmed/32933245
http://dx.doi.org/10.1021/jacs.0c06419

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