Total Synthesis of (−)-Mitrephorone A Enabled by Stereoselective Nitrile Oxide Cycloaddition and Tetrasubstituted Olefin Synthesis

[Image: see text] A highly enantioselective and diastereoselective total synthesis of the diterpenoid (−)-mitrephorone A is presented. Key to the synthesis are stereocontrolled 1,4-semihydrogenation of a 1,3-diene to a tetrasubstituted double bond, enzyme-catalyzed malonate desymmetrization, and hig...

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Detalles Bibliográficos
Autores principales: Schneider, Michael, Richter, Matthieu J. R., Carreira, Erick M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2020
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7564100/
https://www.ncbi.nlm.nih.gov/pubmed/33021371
http://dx.doi.org/10.1021/jacs.0c09520

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7564100/
https://www.ncbi.nlm.nih.gov/pubmed/33021371
http://dx.doi.org/10.1021/jacs.0c09520

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