A Genotyping/Phenotyping Approach with Careful Clinical Monitoring to Manage the Fluoropyrimidines-Based Therapy: Clinical Cases and Systematic Review of the Literature

Fluoropyrimidines (FP) are mainly metabolised by dihydropyrimidine dehydrogenase (DPD), encoded by the DPYD gene. FP pharmacogenetics, including four DPYD polymorphisms (DPYD-PGx), is recommended to tailor the FP-based chemotherapy. These polymorphisms increase the risk of severe toxicity; thus, the...

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Detalles Bibliográficos
Autores principales: Conti, Valeria, De Bellis, Emanuela, Manzo, Valentina, Sabbatino, Francesco, Iannello, Francesco, Dal Piaz, Fabrizio, Izzo, Viviana, Charlier, Bruno, Stefanelli, Berenice, Torsiello, Martina, Iannaccone, Teresa, Coglianese, Albino, Colucci, Francesca, Pepe, Stefano, Filippelli, Amelia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7564232/
https://www.ncbi.nlm.nih.gov/pubmed/32899374
http://dx.doi.org/10.3390/jpm10030113

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7564232/
https://www.ncbi.nlm.nih.gov/pubmed/32899374
http://dx.doi.org/10.3390/jpm10030113

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