Transient Unfolding and Long-Range Interactions in Viral BCL2 M11 Enable Binding to the BECN1 BH3 Domain

Viral BCL2 proteins (vBCL2s) help to sustain chronic infection of host proteins to inhibit apoptosis and autophagy. However, details of conformational changes in vBCL2s that enable binding to BH3Ds remain unknown. Using all-atom, multiple microsecond-long molecular dynamic simulations (totaling 17 [...

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Detalles Bibliográficos
Autores principales: Ramanathan, Arvind, Parvatikar, Akash, Chennubhotla, Srinivas C., Mei, Yang, Sinha, Sangita C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7564285/
https://www.ncbi.nlm.nih.gov/pubmed/32932757
http://dx.doi.org/10.3390/biom10091308

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7564285/
https://www.ncbi.nlm.nih.gov/pubmed/32932757
http://dx.doi.org/10.3390/biom10091308

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