Nuclear Heparanase Regulates Chromatin Remodeling, Gene Expression and PTEN Tumor Suppressor Function

Heparanase (HPSE) is an endoglycosidase that cleaves heparan sulfate and has been shown in various cancers to promote metastasis, angiogenesis, osteolysis, and chemoresistance. Although heparanase is thought to act predominantly extracellularly or within the cytoplasm, it is also present in the nucl...

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Detalles Bibliográficos
Autores principales: Amin, Rada, Tripathi, Kaushlendra, Sanderson, Ralph D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7564302/
https://www.ncbi.nlm.nih.gov/pubmed/32899927
http://dx.doi.org/10.3390/cells9092038

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7564302/
https://www.ncbi.nlm.nih.gov/pubmed/32899927
http://dx.doi.org/10.3390/cells9092038

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