Adjuvantation of an Influenza Hemagglutinin Antigen with TLR4 and NOD2 Agonists Encapsulated in Poly(D,L-Lactide-Co-Glycolide) Nanoparticles Enhances Immunogenicity and Protection against Lethal Influenza Virus Infection in Mice

Along with their excellent safety profiles, subunit vaccines are typically characterized by much weaker immunogenicity and protection efficacy compared to whole-pathogen vaccines. Here, we present an approach aimed at bridging this disadvantage that is based on synergistic collaboration between patt...

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Detalles Bibliográficos
Autores principales: Tukhvatulin, Amir, Dzharullaeva, Alina, Erokhova, Alina, Zemskaya, Anastasia, Balyasin, Maxim, Ozharovskaia, Tatiana, Zubkova, Olga, Shevlyagina, Natalia, Zhukhovitsky, Vladimir, Fedyakina, Irina, Pruss, Ivan, Shcheblyakov, Dmitry, Naroditsky, Boris, Logunov, Denis, Gintsburg, Alexander
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7564367/
https://www.ncbi.nlm.nih.gov/pubmed/32927915
http://dx.doi.org/10.3390/vaccines8030519

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7564367/
https://www.ncbi.nlm.nih.gov/pubmed/32927915
http://dx.doi.org/10.3390/vaccines8030519

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