Systems Biology Approach Identifies Prognostic Signatures of Poor Overall Survival and Guides the Prioritization of Novel BET-CHK1 Combination Therapy for Osteosarcoma

Osteosarcoma (OS) patients exhibit poor overall survival, partly due to copy number variations (CNVs) resulting in dysregulated gene expression and therapeutic resistance. To identify actionable prognostic signatures of poor overall survival, we employed a systems biology approach using public datab...

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Detalles Bibliográficos
Autores principales: Pandya, Pankita H., Cheng, Lijun, Saadatzadeh, M. Reza, Bijangi-Vishehsaraei, Khadijeh, Tang, Shan, Sinn, Anthony L., Trowbridge, Melissa A., Coy, Kathryn L., Bailey, Barbara J., Young, Courtney N., Ding, Jixin, Dobrota, Erika A., Dyer, Savannah, Elmi, Adily, Thompson, Quinton, Barghi, Farinaz, Shultz, Jeremiah, Albright, Eric A., Shannon, Harlan E., Murray, Mary E., Marshall, Mark S., Ferguson, Michael J., Bertrand, Todd E., Wurtz, L. Daniel, Batra, Sandeep, Li, Lang, Renbarger, Jamie L., Pollok, Karen E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7564419/
https://www.ncbi.nlm.nih.gov/pubmed/32859084
http://dx.doi.org/10.3390/cancers12092426

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7564419/
https://www.ncbi.nlm.nih.gov/pubmed/32859084
http://dx.doi.org/10.3390/cancers12092426

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