Calcium, Bioenergetics, and Parkinson’s Disease

Degeneration of substantia nigra (SN) dopaminergic (DAergic) neurons is responsible for the core motor deficits of Parkinson’s disease (PD). These neurons are autonomous pacemakers that have large cytosolic Ca(2+) oscillations that have been linked to basal mitochondrial oxidant stress and turnover....

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Detalles Bibliográficos
Autores principales: Zampese, Enrico, Surmeier, D. James
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7564460/
https://www.ncbi.nlm.nih.gov/pubmed/32911641
http://dx.doi.org/10.3390/cells9092045
Descripción
Sumario:Degeneration of substantia nigra (SN) dopaminergic (DAergic) neurons is responsible for the core motor deficits of Parkinson’s disease (PD). These neurons are autonomous pacemakers that have large cytosolic Ca(2+) oscillations that have been linked to basal mitochondrial oxidant stress and turnover. This review explores the origin of Ca(2+) oscillations and their role in the control of mitochondrial respiration, bioenergetics, and mitochondrial oxidant stress.

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