Calcium, Bioenergetics, and Parkinson’s Disease

Degeneration of substantia nigra (SN) dopaminergic (DAergic) neurons is responsible for the core motor deficits of Parkinson’s disease (PD). These neurons are autonomous pacemakers that have large cytosolic Ca(2+) oscillations that have been linked to basal mitochondrial oxidant stress and turnover....

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Detalles Bibliográficos
Autores principales: Zampese, Enrico, Surmeier, D. James
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7564460/
https://www.ncbi.nlm.nih.gov/pubmed/32911641
http://dx.doi.org/10.3390/cells9092045
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author Zampese, Enrico
Surmeier, D. James
author_facet Zampese, Enrico
Surmeier, D. James
author_sort Zampese, Enrico
collection PubMed
description Degeneration of substantia nigra (SN) dopaminergic (DAergic) neurons is responsible for the core motor deficits of Parkinson’s disease (PD). These neurons are autonomous pacemakers that have large cytosolic Ca(2+) oscillations that have been linked to basal mitochondrial oxidant stress and turnover. This review explores the origin of Ca(2+) oscillations and their role in the control of mitochondrial respiration, bioenergetics, and mitochondrial oxidant stress.
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spelling pubmed-75644602020-10-26 Calcium, Bioenergetics, and Parkinson’s Disease Zampese, Enrico Surmeier, D. James Cells Review Degeneration of substantia nigra (SN) dopaminergic (DAergic) neurons is responsible for the core motor deficits of Parkinson’s disease (PD). These neurons are autonomous pacemakers that have large cytosolic Ca(2+) oscillations that have been linked to basal mitochondrial oxidant stress and turnover. This review explores the origin of Ca(2+) oscillations and their role in the control of mitochondrial respiration, bioenergetics, and mitochondrial oxidant stress. MDPI 2020-09-08 /pmc/articles/PMC7564460/ /pubmed/32911641 http://dx.doi.org/10.3390/cells9092045 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Zampese, Enrico
Surmeier, D. James
Calcium, Bioenergetics, and Parkinson’s Disease
title Calcium, Bioenergetics, and Parkinson’s Disease
title_full Calcium, Bioenergetics, and Parkinson’s Disease
title_fullStr Calcium, Bioenergetics, and Parkinson’s Disease
title_full_unstemmed Calcium, Bioenergetics, and Parkinson’s Disease
title_short Calcium, Bioenergetics, and Parkinson’s Disease
title_sort calcium, bioenergetics, and parkinson’s disease
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7564460/
https://www.ncbi.nlm.nih.gov/pubmed/32911641
http://dx.doi.org/10.3390/cells9092045
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