Loss of the Mitochondrial Fission GTPase Drp1 Contributes to Neurodegeneration in a Drosophila Model of Hereditary Spastic Paraplegia

Mitochondrial morphology, distribution and function are maintained by the opposing forces of mitochondrial fission and fusion, the perturbation of which gives rise to several neurodegenerative disorders. The large guanosine triphosphate (GTP)ase dynamin-related protein 1 (Drp1) is a critical regulat...

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Detalles Bibliográficos
Autores principales: Fowler, Philippa C., Byrne, Dwayne J., Blackstone, Craig, O’Sullivan, Niamh C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7564485/
https://www.ncbi.nlm.nih.gov/pubmed/32957716
http://dx.doi.org/10.3390/brainsci10090646

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7564485/
https://www.ncbi.nlm.nih.gov/pubmed/32957716
http://dx.doi.org/10.3390/brainsci10090646

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