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Multivalent and Bidirectional Binding of Transcriptional Transactivation Domains to the MED25 Coactivator

The human mediator subunit MED25 acts as a coactivator that binds the transcriptional activation domains (TADs) present in various cellular and viral gene-specific transcription factors. Previous studies, including on NMR measurements and site-directed mutagenesis, have only yielded low-resolution m...

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Detalles Bibliográficos
Autores principales: Jeffery, Heather M., Weinzierl, Robert O. J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7564715/
https://www.ncbi.nlm.nih.gov/pubmed/32825095
http://dx.doi.org/10.3390/biom10091205