Cargando…

CCAAT/Enhancer-Binding Protein Delta (C/EBPδ): A Previously Unrecognized Tumor Suppressor that Limits the Oncogenic Potential of Pancreatic Ductal Adenocarcinoma Cells

SIMPLE SUMMARY: Here we show that a protein called C/EBPδ is present in healthy pancreas tissue but almost absent in pancreas tumors. Patients with less C/EBPδ in their tumors had the most metastases and the worst survival chances, showing that C/EBPδ has tumor-suppressive properties in pancreatic c...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hartl, Leonie, Duitman, JanWillem, Aberson, Hella L., Chen, Kan, Dijk, Frederike, Roelofs, Joris J.T.H., Dings, Mark P.G., Hooijer, Gerrit K.J., Hernanda, Pratika Y., Pan, Qiunwei, Busch, Olivier R., Besselink, Marc G.H., Boerman, Ton, Peppelenbosch, Maikel P., Bijlsma, Maarten F., Spek, C. Arnold
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7564797/ https://www.ncbi.nlm.nih.gov/pubmed/32906832 http://dx.doi.org/10.3390/cancers12092546

Ejemplares similares

C/EBP-Family Redundancy Determines Patient Survival and Lymph Node Involvement in PDAC
por: Hartl, Leonie, et al.
Publicado: (2023)

Macrophage C/EBPδ Drives Gemcitabine, but Not 5-FU or Paclitaxel, Resistance of Pancreatic Cancer Cells in a Deoxycytidine-Dependent Manner
por: Spek, C. Arnold, et al.
Publicado: (2022)

Non-Tumor CCAAT/Enhancer-Binding Protein Delta Potentiates Tumor Cell Extravasation and Pancreatic Cancer Metastasis Formation
por: Duitman, JanWillem, et al.
Publicado: (2021)

CCAAT/enhancer binding protein delta (C/EBPδ) deficiency does not affect bleomycin-induced pulmonary fibrosis
por: JanWillem, Duitman, et al.
Publicado: (2018)

CCAAT/enhancer-binding protein δ (C/EBPδ) aggravates inflammation and bacterial dissemination during pneumococcal meningitis
por: Serón, Mercedes Valls, et al.
Publicado: (2015)

Detrimental role for CCAAT/enhancer binding protein δ in blood-borne brain infection
por: Duitman, JanWillem, et al.
Publicado: (2016)

C/EBPδ Suppresses Motility-Associated Gene Signatures and Reduces PDAC Cell Migration
por: Hartl, Leonie, et al.
Publicado: (2022)

Anti-Tumor Effects of Metformin in Animal Models of Hepatocellular Carcinoma: A Systematic Review and Meta-Analysis
por: Li, Juan, et al.
Publicado: (2015)

CEBPD Potentiates the Macrophage Inflammatory Response but CEBPD Knock-Out Macrophages Fail to Identify CEBPD-Dependent Pro-Inflammatory Transcriptional Programs
por: Spek, C. Arnold, et al.
Publicado: (2021)

Macrophage-secreted MMP9 induces mesenchymal transition in pancreatic cancer cells via PAR1 activation
por: Tekin, Cansu, et al.
Publicado: (2020)

Matrix Metalloproteases in Pancreatic Ductal Adenocarcinoma: Key Drivers of Disease Progression?
por: Slapak, Etienne J., et al.
Publicado: (2020)

Is idiopathic pulmonary fibrosis a cancer-like disease? Transcriptome analysis to fuel the debate
por: Spek, C. Arnold, et al.
Publicado: (2019)

PCSK6: The Endogenous PAR-1 Agonist Driving Pulmonary Fibrosis?
por: Spek, C. Arnold, et al.
Publicado: (2023)

Plasmin reduces fibronectin deposition by mesangial cells in a protease-activated receptor-1 independent manner
por: Waasdorp, Maaike, et al.
Publicado: (2017)

Protease-activated receptor-1 deficiency protects against streptozotocin-induced diabetic nephropathy in mice
por: Waasdorp, Maaike, et al.
Publicado: (2016)

Vorapaxar treatment reduces mesangial expansion in streptozotocin-induced diabetic nephropathy in mice
por: Waasdorp, Maaike, et al.
Publicado: (2018)

Immune Checkpoints as Promising Targets for the Treatment of Idiopathic Pulmonary Fibrosis?
por: Duitman, JanWillem, et al.
Publicado: (2019)

CCAAT/Enhancer Binding Protein-delta (C/EBP-delta) regulates cell growth, migration and differentiation
por: Yu, Xueyan, et al.
Publicado: (2010)

The expression of CCAAT/enhancer binding protein (C/EBP) in the human ovary in vivo: specific increase in C/EBPβ during epithelial tumour progression
por: Sundfeldt, K, et al.
Publicado: (1999)

Early macrophage infiltrates impair pancreatic cancer cell growth by TNF-α secretion
por: Tekin, Cansu, et al.
Publicado: (2020)

Reciprocal Roles for CCAAT/Enhancer Binding Protein (C/EBP) and PU.1 Transcription Factors in Langerhans Cell Commitment
por: Iwama, Atsushi, et al.
Publicado: (2002)

Repression of Smoothened by Patched-Dependent (Pro-)Vitamin D3 Secretion
por: Bijlsma, Maarten F, et al.
Publicado: (2006)

The CCAAT/enhancer binding protein (C/EBP) δ is differently regulated by fibrillar and oligomeric forms of the Alzheimer amyloid-β peptide
por: Ramberg, Veronica, et al.
Publicado: (2011)

SAT-333 CCAAT Enhancer Binding Protein Β(C/EBPΒ)-induced Axl in Early Breast Cancer Progression
por: Burke, Caitlin, et al.
Publicado: (2019)

Protease‐activated receptor‐1 contributes to renal injury and interstitial fibrosis during chronic obstructive nephropathy
por: Waasdorp, Maaike, et al.
Publicado: (2018)

Tumor promotion through the mesenchymal stem cell compartment in human hepatocellular carcinoma
por: Hernanda, Pratika Y., et al.
Publicado: (2013)

Protein-x of hepatitis B virus in interaction with CCAAT/enhancer-binding protein α (C/EBPα) - an in silico analysis approach
por: Mohamadkhani, Ashraf, et al.
Publicado: (2011)

CCAAT/enhancer binding protein delta (C/EBPδ) demonstrates a dichotomous role in tumour initiation and promotion of epithelial carcinoma
por: Sowamber, Ramlogan, et al.
Publicado: (2019)

Sulforaphene Suppresses Adipocyte Differentiation via Induction of Post-Translational Degradation of CCAAT/Enhancer Binding Protein Beta (C/EBPβ)
por: Yang, Hee, et al.
Publicado: (2020)

Deubiquitinase USP1 enhances CCAAT/enhancer-binding protein beta (C/EBPβ) stability and accelerates adipogenesis and lipid accumulation
por: Kim, Myung Sup, et al.
Publicado: (2023)

Myeloid DNA methyltransferase3b deficiency aggravates pulmonary fibrosis by enhancing profibrotic macrophage activation
por: Qin, Wanhai, et al.
Publicado: (2022)

Stat3 and CCAAT enhancer–binding protein β (C/ebpβ) activate Fanconi C gene transcription during emergency granulopoiesis
por: Shah, Chirag A., et al.
Publicado: (2018)

Differential effects of sumoylation on the activities of CCAAT enhancer binding protein alpha (C/EBPα) p42 versus p30 may contribute in part, to aberrant C/EBPα activity in acute leukemias
por: Hankey, William, et al.
Publicado: (2011)

Stat3 and CCAAT/enhancer binding protein beta (C/EBP-beta) regulate Jab1/CSN5 expression in mammary carcinoma cells
por: Shackleford, Terry J, et al.
Publicado: (2011)

Upregulation of Interleukin 6 and Granulocyte Colony-Stimulating Factor Receptors by Transcription Factor CCAAT Enhancer Binding Protein α (C/EBPα) Is Critical for Granulopoiesis
por: Zhang, Pu, et al.
Publicado: (1998)

Expression and Activity of the Transcription Factor CCAAT/Enhancer-Binding Protein β (C/EBPβ) Is Regulated by Specific Pulse-Modulated Radio Frequencies in Oligodendroglial Cells
por: Huang, Bing, et al.
Publicado: (2023)

The transcription factor ccaat/enhancer binding protein β (C/EBPβ) and miR-27a regulate the expression of porcine Dickkopf2 (DKK2)
por: Tao, Hu, et al.
Publicado: (2015)

Identification of DNA response elements regulating expression of CCAAT/enhancer-binding protein (C/EBP) β and δ and MAP kinase-interacting kinases during early adipogenesis
por: Merrett, James E., et al.
Publicado: (2020)

Hearing disability in patients with Fuchs’ endothelial corneal dystrophy: unrecognized co-pathology?
por: Stehouwer, Marilette, et al.
Publicado: (2011)

The coagulation factor Xa/protease activated receptor-2 axis in the progression of liver fibrosis: a multifaceted paradigm
por: Borensztajn, Keren, et al.
Publicado: (2010)

Cannot write session to /tmp/vufind_sessions/sess_mfmde2882fngu4ni4nckoqhmon