Genetically encoded protein sulfation in mammalian cells

Tyrosine sulfation is an important post-translational modification found in higher eukaryotes. Here we report an engineered tyrosyl-tRNA synthetase/tRNA pair that co-translationally incorporates O-sulfotyrosine in response to UAG codons in E. coli and mammalian cells. This platform enables recombina...

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Detalles Bibliográficos
Autores principales: Italia, James S., Peeler, Jennifer C., Hillenbrand, Christen M., Latour, Christopher, Weerapana, Eranthie, Chatterjee, Abhishek
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7564891/
https://www.ncbi.nlm.nih.gov/pubmed/32198493
http://dx.doi.org/10.1038/s41589-020-0493-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7564891/
https://www.ncbi.nlm.nih.gov/pubmed/32198493
http://dx.doi.org/10.1038/s41589-020-0493-1

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