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Genetically encoded protein sulfation in mammalian cells
Tyrosine sulfation is an important post-translational modification found in higher eukaryotes. Here we report an engineered tyrosyl-tRNA synthetase/tRNA pair that co-translationally incorporates O-sulfotyrosine in response to UAG codons in E. coli and mammalian cells. This platform enables recombina...
Autores principales: | Italia, James S., Peeler, Jennifer C., Hillenbrand, Christen M., Latour, Christopher, Weerapana, Eranthie, Chatterjee, Abhishek |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7564891/ https://www.ncbi.nlm.nih.gov/pubmed/32198493 http://dx.doi.org/10.1038/s41589-020-0493-1 |
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