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Lessons from Bacillus Calmette-Guérin: Harnessing Trained Immunity for Vaccine Development
Vaccine design traditionally focuses on inducing adaptive immune responses against a sole target pathogen. Considering that many microbes evade innate immune mechanisms to initiate infection, and in light of the discovery of epigenetically mediated innate immune training, the paradigm of vaccine des...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7564904/ https://www.ncbi.nlm.nih.gov/pubmed/32948003 http://dx.doi.org/10.3390/cells9092109 |