Histidine Residues Are Responsible for Bidirectional Effects of Zinc on Acid-Sensing Ion Channel 1a/3 Heteromeric Channels

Acid-sensing ion channel (ASIC) subunits 1a and 3 are highly expressed in central and peripheral sensory neurons, respectively. Endogenous biomolecule zinc plays a critical role in physiological and pathophysiological conditions. Here, we found that currents recorded from heterologously expressed AS...

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Detalles Bibliográficos
Autores principales: Jiang, Qian, Peterson, Andrew M., Chu, Yuyang, Yao, Xiaolan, Zha, Xiang-ming, Chu, Xiang-Ping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7565092/
https://www.ncbi.nlm.nih.gov/pubmed/32887365
http://dx.doi.org/10.3390/biom10091264

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7565092/
https://www.ncbi.nlm.nih.gov/pubmed/32887365
http://dx.doi.org/10.3390/biom10091264

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