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Histidine Residues Are Responsible for Bidirectional Effects of Zinc on Acid-Sensing Ion Channel 1a/3 Heteromeric Channels
Acid-sensing ion channel (ASIC) subunits 1a and 3 are highly expressed in central and peripheral sensory neurons, respectively. Endogenous biomolecule zinc plays a critical role in physiological and pathophysiological conditions. Here, we found that currents recorded from heterologously expressed AS...
Autores principales: | Jiang, Qian, Peterson, Andrew M., Chu, Yuyang, Yao, Xiaolan, Zha, Xiang-ming, Chu, Xiang-Ping |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7565092/ https://www.ncbi.nlm.nih.gov/pubmed/32887365 http://dx.doi.org/10.3390/biom10091264 |
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