Essentiality and Transcriptome-Enriched Pathway Scores Predict Drug-Combination Synergy

In the prediction of the synergy of drug combinations, systems pharmacology models expand the scope of experiment screening and overcome the limitations of current computational models posed by their lack of mechanical interpretation and integration of gene essentiality. We therefore investigated th...

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Detalles Bibliográficos
Autores principales: Li, Jin, Huo, Yang, Wu, Xue, Liu, Enze, Zeng, Zhi, Tian, Zhen, Fan, Kunjie, Stover, Daniel, Cheng, Lijun, Li, Lang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7565142/
https://www.ncbi.nlm.nih.gov/pubmed/32906805
http://dx.doi.org/10.3390/biology9090278

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7565142/
https://www.ncbi.nlm.nih.gov/pubmed/32906805
http://dx.doi.org/10.3390/biology9090278

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