Cargando…

pH-Channeling in Cancer: How pH-Dependence of Cation Channels Shapes Cancer Pathophysiology

Tissue acidosis plays a pivotal role in tumor progression: in particular, interstitial acidosis promotes tumor cell invasion, and is a major contributor to the dysregulation of tumor immunity and tumor stromal cells. The cell membrane and integral membrane proteins commonly act as important sensors...

Descripción completa

Detalles Bibliográficos
Autores principales:	Pethő, Zoltán, Najder, Karolina, Carvalho, Tiago, McMorrow, Roisin, Todesca, Luca Matteo, Rugi, Micol, Bulk, Etmar, Chan, Alan, Löwik, Clemens W. G. M., Reshkin, Stephan J., Schwab, Albrecht
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7565548/ https://www.ncbi.nlm.nih.gov/pubmed/32887220 http://dx.doi.org/10.3390/cancers12092484

Ejemplares similares

Role of the Intracellular Sodium Homeostasis in Chemotaxis of Activated Murine Neutrophils
por: Najder, Karolina, et al.
Publicado: (2020)

The Role of TRP Channels in the Metastatic Cascade
por: Fels, Benedikt, et al.
Publicado: (2018)

Functional expression of mitochondrial K(Ca)3.1 channels in non-small cell lung cancer cells
por: Bulk, Etmar, et al.
Publicado: (2022)

Ion Channels Orchestrate Pancreatic Ductal Adenocarcinoma Progression and Therapy
por: Hofschröer, Verena, et al.
Publicado: (2021)

Importance of pH in Synthesis of pH-Responsive Cationic Nano- and Microgels
por: Annegarn, Marco, et al.
Publicado: (2021)

Reduced H(+) channel activity disrupts pH homeostasis and calcification in coccolithophores at low ocean pH
por: Kottmeier, Dorothee M., et al.
Publicado: (2022)

The context-dependent role of the Na(+)/Ca(2+)-exchanger (NCX) in pancreatic stellate cell migration
por: Loeck, Thorsten, et al.
Publicado: (2023)

Computational Tools for Interpreting Ion Channel pH-Dependence
por: Sazanavets, Ivan, et al.
Publicado: (2015)

CO(2)chemotransduction in central neurons: role of intracellular pH (pH(i)) and extracellular pH (pH(o))
por: Putnam, RW
Publicado: (2001)

K(Ca) channel blockers increase effectiveness of the EGF receptor TK inhibitor erlotinib in non-small cell lung cancer cells (A549)
por: Glaser, Felix, et al.
Publicado: (2021)

Co‐staining of K(Ca)3.1 Channels in NSCLC Cells with a Small‐Molecule Fluorescent Probe and Antibody‐Based Indirect Immunofluorescence
por: Brömmel, Kathrin, et al.
Publicado: (2020)

Curing cancer? Further along the new pH-centric road and paradigm
por: Harguindey, S., et al.
Publicado: (2018)

pH dependence of the acetylcholine receptor channel: a species variation
Publicado: (1981)

State-dependent Inhibition of TRPM2 Channel by Acidic pH
por: Yang, Wei, et al.
Publicado: (2010)

The pH sensitivity of Aqp0 channels in tetraploid and diploid teleosts
por: Chauvigné, François, et al.
Publicado: (2015)

The Effect of pH and Ion Channel Modulators on Human Placental Arteries
por: Ali, Tayyba Y, et al.
Publicado: (2014)

Structures and pH sensing mechanism of proton-activated chloride channel
por: Ruan, Zheng, et al.
Publicado: (2020)

Molecular determinants of pH sensing in the proton-activated chloride channel
por: Osei-Owusu, James, et al.
Publicado: (2022)

Computational Investigation of Mechanisms for pH Modulation of Human Chloride Channels
por: Elverson, Kathleen, et al.
Publicado: (2023)

A Voltage-Gated H(+) Channel Underlying pH Homeostasis in Calcifying Coccolithophores
por: Taylor, Alison R., et al.
Publicado: (2011)

The acid test for pH-dependent gating in cloned H(V)1 channels
por: Islas, León D.
Publicado: (2018)

Voltage and pH sensing by the voltage-gated proton channel, H(V)1
por: DeCoursey, Thomas E.
Publicado: (2018)

Evidence for the adaptation of protein pH-dependence to subcellular pH
por: Chan, Pedro, et al.
Publicado: (2009)

Esophageal pH and Combined Impedance-pH Monitoring in Children
por: Shin, Myung Seok
Publicado: (2014)

The pH of Drinking Water and Its Effect on the pH of Urine
por: Yıldırım, İlker, et al.
Publicado: (2023)

Reduction of Skin pH during Treatment for Palmoplantar Hyperhidrosis: A Conjecture on the Role of pH-Regulated Water Channel, i.e. Aquaporin
por: Nakahigashi, Kyoko, et al.
Publicado: (2013)

Na(+)/H(+) Exchangers Involve in Regulating the pH-Sensitive Ion Channels in Mouse Sperm
por: Kang, Hang, et al.
Publicado: (2021)

pH-regulated Slo3 K(+) Channels: Properties of Unitary Currents
por: Zhang, Xue, et al.
Publicado: (2006)

Slo3 K(+) Channels: Voltage and pH Dependence of Macroscopic Currents
por: Zhang, Xue, et al.
Publicado: (2006)

pH regulation of amphotericin B channels activity in the bilayer lipid membrane
por: Shahmoradi, Tahereh, et al.
Publicado: (2016)

Relation between pH in the Trunk and Face: Truncal pH Can Be Easily Predicted from Facial pH
por: Kim, Sung Ae, et al.
Publicado: (2016)

Decreased Brain pH and Pathophysiology in Schizophrenia
por: Park, Hae-Jeong, et al.
Publicado: (2021)

Charge Screening by Internal pH and Polyvalent Cations as a Mechanism for Activation, Inhibition, and Rundown of TRPM7/MIC Channels
por: Kozak, J. Ashot, et al.
Publicado: (2005)

Cation- and pH-Dependent Hydrogen Evolution and Oxidation Reaction Kinetics
por: Huang, Botao, et al.
Publicado: (2021)

Influence of cations, pH and dispersed phases on pectin emulsification properties
por: Ürüncüoğlu, Şerife, et al.
Publicado: (2021)

Synthesis and mechanistic investigations of pH-responsive cationic poly(aminoester)s
por: Blake, Timothy R., et al.
Publicado: (2020)

The pH and conductivity : handbook
Publicado: (1995)

Role of pH in Regulating Cancer Pyrimidine Synthesis
por: Alqahtani, Saad Saeed, et al.
Publicado: (2022)

Conotoxins as Sensors of Local pH and Electrostatic Potential in the Outer Vestibule of the Sodium Channel
por: Hui, Kwokyin, et al.
Publicado: (2003)

A discussion of Ambystoma kidney tubule ion channels, transporters, and pH regulation.
por: Bock, J. F.
Publicado: (1990)

Cannot write session to /tmp/vufind_sessions/sess_2qth6mglt2e881gleeen57lfsn