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Raloxifene and n-Acetylcysteine Ameliorate TGF-Signalling in Fibroblasts from Patients with Recessive Dominant Epidermolysis Bullosa

Recessive dystrophic epidermolysis bullosa (RDEB) is a severe skin disease caused by mutation of the COL7A1 gene. RDEB is associated with high levels of TGF-β1, which is likely to be involved in the fibrosis that develops in this disease. Endoglin (CD105) is a type III coreceptor for TGF-β1 and its...

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Detalles Bibliográficos
Autores principales: Aguado, Tania, García, Marta, García, Adela, Ferrer-Mayorga, Gemma, Martínez-Santamaría, Lucía, del Río, Marcela, Botella, Luisa-María, Sánchez-Puelles, José-María
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7565802/
https://www.ncbi.nlm.nih.gov/pubmed/32947957
http://dx.doi.org/10.3390/cells9092108