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Nucleotide Loading Modes of Human RNA Polymerase II as Deciphered by Molecular Simulations

Mapping the route of nucleoside triphosphate (NTP) entry into the sequestered active site of RNA polymerase (RNAP) has major implications for elucidating the complete nucleotide addition cycle. Constituting a dichotomy that remains to be resolved, two alternatives, direct NTP delivery via the second...

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Detalles Bibliográficos
Autores principales: Génin, Nicolas E. J., Weinzierl, Robert O. J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7565877/
https://www.ncbi.nlm.nih.gov/pubmed/32906795
http://dx.doi.org/10.3390/biom10091289