Multiple Mutations in Mycobacterium tuberculosis MmpL3 Increase Resistance to MmpL3 Inhibitors

The Mycobacterium tuberculosis protein MmpL3 performs an essential role in cell wall synthesis, since it effects the transport of trehalose monomycolates across the inner membrane. Numerous structurally diverse pharmacophores have been identified as inhibitors of MmpL3 largely based on the identific...

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Detalles Bibliográficos
Autores principales: McNeil, Matthew B., O’Malley, Theresa, Dennison, Devon, Shelton, Catherine D., Sunde, Bjorn, Parish, Tanya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7565900/
https://www.ncbi.nlm.nih.gov/pubmed/33055263
http://dx.doi.org/10.1128/mSphere.00985-20

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7565900/
https://www.ncbi.nlm.nih.gov/pubmed/33055263
http://dx.doi.org/10.1128/mSphere.00985-20

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