Caveolin-1-Mediated Tumor Suppression Is Linked to Reduced HIF1α S-Nitrosylation and Transcriptional Activity in Hypoxia

Caveolin-1 (CAV1) is a well-established nitric oxide synthase inhibitor, whose function as a tumor suppressor is favored by, but not entirely dependent on, the presence of E-cadherin. Tumors are frequently hypoxic and the activation of the hypoxia-inducible factor-1α (HIF1α) promotes tumor growth. H...

Descripción completa

Detalles Bibliográficos
Autores principales: Sanhueza, Carlos, Bennett, Jimena Castillo, Valenzuela-Valderrama, Manuel, Contreras, Pamela, Lobos-González, Lorena, Campos, América, Wehinger, Sergio, Lladser, Álvaro, Kiessling, Rolf, Leyton, Lisette, Quest, Andrew F.G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7565942/
https://www.ncbi.nlm.nih.gov/pubmed/32825247
http://dx.doi.org/10.3390/cancers12092349

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7565942/
https://www.ncbi.nlm.nih.gov/pubmed/32825247
http://dx.doi.org/10.3390/cancers12092349

Ejemplares similares