A Phosphorylation-Induced Switch in the Nuclear Localization Sequence of the Intrinsically Disordered NUPR1 Hampers Binding to Importin

Several carrier proteins are involved in protein transport from the cytoplasm to the nucleus in eukaryotic cells. One of those is importin α, of which there are several human isoforms; among them, importin α3 (Impα3) has a high flexibility. The protein NUPR1, a nuclear protein involved in the cell-s...

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Detalles Bibliográficos
Autores principales: Neira, José L., Rizzuti, Bruno, Jiménez-Alesanco, Ana, Palomino-Schätzlein, Martina, Abián, Olga, Velázquez-Campoy, Adrián, Iovanna, Juan L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7565984/
https://www.ncbi.nlm.nih.gov/pubmed/32933064
http://dx.doi.org/10.3390/biom10091313

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7565984/
https://www.ncbi.nlm.nih.gov/pubmed/32933064
http://dx.doi.org/10.3390/biom10091313

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