Cargando…

Insight into the Anticancer Activity of Copper(II) 5-Methylenetrimethylammonium-Thiosemicarbazonates and Their Interaction with Organic Cation Transporters

A series of four water-soluble salicylaldehyde thiosemicarbazones with a positively charged trimethylammonium moiety ([H(2)L(R)]Cl, R = H, Me, Et, Ph) and four copper(II) complexes [Cu(HL(R))Cl]Cl (1–4) were synthesised with the aim to study (i) their antiproliferative activity in cancer cells and,...

Descripción completa

Detalles Bibliográficos
Autores principales:	Milunović, Miljan N. M., Palamarciuc, Oleg, Sirbu, Angela, Shova, Sergiu, Dumitrescu, Dan, Dvoranová, Dana, Rapta, Peter, Petrasheuskaya, Tatsiana V., Enyedy, Eva A., Spengler, Gabriella, Ilic, Marija, Sitte, Harald H., Lubec, Gert, Arion, Vladimir B.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7565988/ https://www.ncbi.nlm.nih.gov/pubmed/32825480 http://dx.doi.org/10.3390/biom10091213

Ejemplares similares

Copper(II) Thiosemicarbazone Complexes and Their Proligands upon UVA Irradiation: An EPR and Spectrophotometric Steady-State Study
por: Hricovíni, Michal, et al.
Publicado: (2018)

Triapine Analogues and Their Copper(II) Complexes: Synthesis, Characterization, Solution Speciation, Redox Activity, Cytotoxicity, and mR2 RNR Inhibition
por: Besleaga, Iuliana, et al.
Publicado: (2021)

Coumarin-Based Triapine Derivatives and Their Copper(II) Complexes: Synthesis, Cytotoxicity and mR2 RNR Inhibition Activity
por: Stepanenko, Iryna, et al.
Publicado: (2021)

New Water-Soluble Copper(II) Complexes with Morpholine–Thiosemicarbazone Hybrids: Insights into the Anticancer and Antibacterial Mode of Action
por: Ohui, Kateryna, et al.
Publicado: (2018)

Diastereomeric dinickel(ii) complexes with non-innocent bis(octaazamacrocyclic) ligands: isomerization, spectroelectrochemistry, DFT calculations and use in catalytic oxidation of cyclohexane
por: Dobrov, Anatolie, et al.
Publicado: (2022)

Estradiol-Based Salicylaldehyde (Thio)Semicarbazones and Their Copper Complexes with Anticancer, Antibacterial and Antioxidant Activities
por: Petrasheuskaya, Tatsiana V., et al.
Publicado: (2022)

Binding Models of Copper(II) Thiosemicarbazone Complexes with Human Serum Albumin: A Speciation Study
por: May, Nóra V., et al.
Publicado: (2021)

Thiosemicarbazone Derivatives Developed to Overcome COTI-2 Resistance
por: Pósa, Vivien, et al.
Publicado: (2022)

Cell-Based Radiotracer Binding and Uptake Inhibition Assays: A Comparison of In Vitro Methods to Assess the Potency of Drugs That Target Monoamine Transporters
por: Ilic, Marija, et al.
Publicado: (2020)

Corrigendum: Cell-Based Radiotracer Binding and Uptake Inhibition Assays: A Comparison of In Vitro Methods to Assess the Potency of Drugs That Target Monoamine Transporters
por: Ilic, Marija, et al.
Publicado: (2022)

α-N-Heterocyclic thiosemicarbazones induce ER stress-mediated CHOP activation
por: Trondl, Robert, et al.
Publicado: (2010)

Ruthenium-Nitrosyl Complexes with Glycine, l-Alanine, l-Valine, l-Proline, d-Proline, l-Serine, l-Threonine, and l-Tyrosine: Synthesis, X-ray Diffraction Structures, Spectroscopic and Electrochemical Properties, and Antiproliferative Activity
por: Rathgeb, Anna, et al.
Publicado: (2014)

Crystal structures of the complexes containing macrocyclic cations [M(cyclam)](2+) (M = Ni, Zn) and tetraiodidocadmate(2–) anion
por: Andriichuk, Irina L., et al.
Publicado: (2023)

Syntheses and structural characterizations of the first coordination polymers assembled from the Ni(cyclam)(2+) cation and the benzene-1,3,5-tricarboxylate linker
por: Gavrish, Sergey P., et al.
Publicado: (2022)

Synthesis of 1-(2-Fluorophenyl)pyrazoles by 1,3-Dipolar Cycloaddition of the Corresponding Sydnones
por: Dumitrescu, Denisa, et al.
Publicado: (2021)

Crystal structure of the one-dimensional coordination polymer formed by the macrocyclic [Ni(cyclam)](2+) cation and the dianion of diphenylsilanediylbis(4-benzoic acid)
por: Gavrish, Sergey P., et al.
Publicado: (2020)

Highly Antiproliferative Latonduine and Indolo[2,3-c]quinoline Derivatives: Complex Formation with Copper(II) Markedly Changes the Kinase Inhibitory Profile
por: Wittmann, Christopher, et al.
Publicado: (2022)

Solution Equilibrium Studies on Salicylidene Aminoguanidine Schiff Base Metal Complexes: Impact of the Hybridization with L-Proline on Stability, Redox Activity and Cytotoxicity
por: Dömötör, Orsolya, et al.
Publicado: (2022)

Benzaldehyde thiosemicarbazone
por: Kong, Lingqian, et al.
Publicado: (2008)

The Release of a Highly Cytotoxic Paullone Bearing a TEMPO Free Radical from the HSA Hydrogel: An EPR Spectroscopic Characterization
por: Vesković, Ana, et al.
Publicado: (2022)

Benzaldehyde thiosemicarbazone monohydrate
por: Gu, Sheng-Jiu, et al.
Publicado: (2008)

A comparison of the transport kinetics of glycine transporter 1 and glycine transporter 2
por: Erdem, Fatma Asli, et al.
Publicado: (2019)

Syntheses and crystal structures of the one-dimensional coordination polymers formed by [Ni(cyclam)](2+) cations and 1,3-bis(3-carboxypropyl)tetramethyldisiloxane anions in different degrees of deprotonation
por: Gavrish, Sergey P., et al.
Publicado: (2020)

Crystal structure of [{[Ni(C(10)H(24)N(4))][Ni(CN)(4)]}·2H(2)O]( n ), a one-dimensional coordination polymer formed from the [Ni(cyclam)](2+) cation and the [Ni(CN)(4)](2–) anion
por: Tsymbal, Liudmyla V., et al.
Publicado: (2021)

Triapine Derivatives Act as Copper Delivery Vehicles to Induce Deadly Metal Overload in Cancer Cells
por: Ohui, Kateryna, et al.
Publicado: (2020)

(E)-4-Octyloxybenzaldehyde thiosemicarbazone
por: Islam, M. A. A. A. A., et al.
Publicado: (2009)

3-Nitrobenzaldehyde thiosemicarbazone
por: Wu, De-Hong, et al.
Publicado: (2008)

Synthesis and Structural Characterization of Fluorinated Thiosemicarbazones
por: Bautista, Juan L., et al.
Publicado: (2013)

Modification of Polyacrylonitrile Fibers by Coupling to Thiosemicarbazones
por: Yao, Yao, et al.
Publicado: (2019)

Inhibition of Topoisomerases by Metal Thiosemicarbazone Complexes
por: Jiang, Xiaohua, et al.
Publicado: (2023)

Introducing chirality in halogenated 3-arylsydnones and their corresponding 1-arylpyrazoles obtained by 1,3-dipolar cycloaddition
por: Popa, Marcel Mirel, et al.
Publicado: (2020)

R-Modafinil exerts weak effects on spatial memory acquisition and dentate gyrus synaptic plasticity
por: Shanmugasundaram, Bharanidharan, et al.
Publicado: (2017)

Cancer Cell Resistance Against the Clinically Investigated Thiosemicarbazone COTI-2 Is Based on Formation of Intracellular Copper Complex Glutathione Adducts and ABCC1-Mediated Efflux
por: Bormio Nunes, Julia H., et al.
Publicado: (2020)

Indolo[2,3-e]benzazocines and indolo[2,3-f]benzazonines and their copper(ii) complexes as microtubule destabilizing agents
por: Wittmann, Christopher, et al.
Publicado: (2023)

2,5-Dimethoxybenzaldehyde thiosemicarbazone
por: Fun, Hoong-Kun, et al.
Publicado: (2008)

Antifungal and Antioxidant Activities of Pyrrolidone Thiosemicarbazone Complexes
por: Al-Amiery, Ahmed A., et al.
Publicado: (2012)

Ferrocene-1-carbaldehyde thiosemicarbazone
por: Vikneswaran, M. R., et al.
Publicado: (2010)

4-Cyanobenzaldehyde thiosemicarbazone
por: Wu, De-Hong, et al.
Publicado: (2008)

3-Methoxybenzaldehyde thiosemicarbazone
por: Zhang, Jian, et al.
Publicado: (2009)

Pyridine-2-carbaldehyde thiosemicarbazone
por: Song, Li-Hua, et al.
Publicado: (2009)

Cannot write session to /tmp/vufind_sessions/sess_r9fi1s77gl072m02bu8015mbk9