Discovery of a Novel Natural Allosteric Inhibitor That Targets NDM-1 Against Escherichia coli

At present, the resistance of New Delhi metallo-β-lactamase-1 (NDM-1) to carbapenems and cephalosporins, one of the mechanisms of bacterial resistance against β-lactam antibiotics, poses a threat to human health. In this work, based on the virtual ligand screen method, we found that carnosic acid (C...

Descripción completa

Detalles Bibliográficos
Autores principales: Yang, Yanan, Guo, Yan, Zhou, Yonglin, Gao, Yawen, Wang, Xiyan, Wang, Jianfeng, Niu, Xiaodi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7566295/
https://www.ncbi.nlm.nih.gov/pubmed/33123013
http://dx.doi.org/10.3389/fphar.2020.581001

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7566295/
https://www.ncbi.nlm.nih.gov/pubmed/33123013
http://dx.doi.org/10.3389/fphar.2020.581001

Ejemplares similares