Cargando…

CXCR1 and CXCR2 Inhibition by Ladarixin Improves Neutrophil-Dependent Airway Inflammation in Mice

RATIONALE: Increased IL-8 levels and neutrophil accumulation in the airways are common features found in patients affected by pulmonary diseases such as Asthma, Idiopathic Pulmonary Fibrosis, Influenza-A infection and COPD. Chronic neutrophilic inflammation is usually corticosteroid insensitive and...

Descripción completa

Detalles Bibliográficos
Autores principales:	Mattos, Matheus Silverio, Ferrero, Maximiliano Ruben, Kraemer, Lucas, Lopes, Gabriel Augusto Oliveira, Reis, Diego Carlos, Cassali, Geovanni Dantas, Oliveira, Fabricio Marcus Silva, Brandolini, Laura, Allegretti, Marcello, Garcia, Cristiana Couto, Martins, Marco Aurélio, Teixeira, Mauro Martins, Russo, Remo Castro
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2020
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7566412/ https://www.ncbi.nlm.nih.gov/pubmed/33123138 http://dx.doi.org/10.3389/fimmu.2020.566953

Ejemplares similares

CXCR1/2 Inhibitor Ladarixin Ameliorates the Insulin Resistance of 3T3-L1 Adipocytes by Inhibiting Inflammation and Improving Insulin Signaling
por: Castelli, Vanessa, et al.
Publicado: (2021)

Ladarixin, an inhibitor of the interleukin‐8 receptors CXCR1 and CXCR2, in new‐onset type 1 diabetes: A multicentre, randomized, double‐blind, placebo‐controlled trial
por: Piemonti, Lorenzo, et al.
Publicado: (2022)

Ladarixin, a dual CXCR1/2 inhibitor, attenuates experimental melanomas harboring different molecular defects by affecting malignant cells and tumor microenvironment
por: Kemp, Daria Marley, et al.
Publicado: (2017)

CXCR1/2 pathways in paclitaxel-induced neuropathic pain
por: Laura, Brandolini, et al.
Publicado: (2017)

Intravital Microscopic Evaluation of the Effects of a CXCR2 Antagonist in a Model of Liver Ischemia Reperfusion Injury in Mice
por: de Oliveira, Thiago Henrique Caldeira, et al.
Publicado: (2018)

The CXCR1/CXCR2 Inhibitor Reparixin Alters the Development of Myelofibrosis in the Gata1 (low) Mice
por: Verachi, Paola, et al.
Publicado: (2022)

CXCR1/2 Antagonism Is Protective during Influenza and Post-Influenza Pneumococcal Infection
por: Tavares, Luciana P., et al.
Publicado: (2017)

Targeting CXCR1 on breast cancer stem cells: signaling pathways and clinical application modelling
por: Brandolini, Laura, et al.
Publicado: (2015)

Versican and Tumor-Associated Macrophages Promotes Tumor Progression and Metastasis in Canine and Murine Models of Breast Carcinoma
por: dos Reis, Diego Carlos, et al.
Publicado: (2019)

Comparative mammary oncology: canine model
por: Cassali, Geovanni Dantas
Publicado: (2013)

The Role of CXCR1, CXCR2, CXCR3, CXCR5, and CXCR6 Ligands in Molecular Cancer Processes and Clinical Aspects of Acute Myeloid Leukemia (AML)
por: Korbecki, Jan, et al.
Publicado: (2023)

Inflammation-Independent Antinociceptive Effects of DF2755A, a CXCR1/2 Selective Inhibitor: A New Potential Therapeutic Treatment for Peripheral Neuropathy Associated to Non-Ulcerative Interstitial Cystitis/Bladder Pain Syndrome
por: Brandolini, Laura, et al.
Publicado: (2022)

Computer‐aided assessment of the chemokine receptors CXCR3, CXCR4 and CXCR7 expression in gallbladder carcinoma
por: Yu, Xiao, et al.
Publicado: (2020)

A homeostatic function of CXCR2 signalling in articular cartilage
por: Sherwood, Joanna, et al.
Publicado: (2015)

CXCR7 Controls Competition for Recruitment of β-Arrestin 2 in Cells Expressing Both CXCR4 and CXCR7
por: Coggins, Nathaniel L., et al.
Publicado: (2014)

CXCR4 and CXCR3 are two distinct prognostic biomarkers in breast cancer: Database mining for CXCR family members
por: Guo, Kaibo, et al.
Publicado: (2019)

Opposing roles of CXCR4 and CXCR7 in breast cancer metastasis
por: Hernandez, Lorena, et al.
Publicado: (2011)

Correlation of CXCR4/CXCR7 signaling pathway with pre-eclampsia
por: Zheng, Zhi, et al.
Publicado: (2018)

Specific Receptors for the Chemokines CXCR2 and CXCR4 in Pancreatic Cancer
por: Litman-Zawadzka, Ala, et al.
Publicado: (2020)

Inhibition of CXCR4 and CXCR7 Is Protective in Acute Peritoneal Inflammation
por: Ngamsri, Kristian-Christos, et al.
Publicado: (2020)

CXCR1 and CXCR2 enhances human melanoma tumourigenesis, growth and invasion
por: Singh, S, et al.
Publicado: (2009)

Hypoxia differentially regulated CXCR4 and CXCR7 signaling in colon cancer
por: Romain, Benoît, et al.
Publicado: (2014)

Expression and function of CXCL12/CXCR4/CXCR7 in thyroid cancer
por: ZHU, XIAOLI, et al.
Publicado: (2016)

CXCR4/CXCR7/CXCL12-Axis in Follicular Thyroid Carcinoma
por: Werner, Thomas Artur, et al.
Publicado: (2018)

Differences in Sulfotyrosine Binding amongst CXCR1 and CXCR2 Chemokine Ligands
por: Moussouras, Natasha A., et al.
Publicado: (2017)

The Role of the CXCL12/CXCR4/CXCR7 Chemokine Axis in Cancer
por: Shi, Yi, et al.
Publicado: (2020)

CXCR4/CXCR7 Protein Expression Levels in Placentas of Patients with Preeclampsia
por: Zheng, Zhi, et al.
Publicado: (2021)

Involvement of CXCR4/CXCR7/CXCL12 Interactions in Inflammatory Bowel Disease
por: Werner, Lael, et al.
Publicado: (2013)

The dynamic yin-yang interaction of CXCR4 and CXCR7 in breast cancer metastasis
por: Hawkins, Oriana E, et al.
Publicado: (2012)

Chemokine Receptors, CXCR1 and CXCR2, Differentially Regulate Exosome Release in Hepatocytes
por: Nojima, Hiroyuki, et al.
Publicado: (2016)

Impact of the Chemokine Receptors CXCR4 and CXCR7 on Clinical Outcome in Adrenocortical Carcinoma
por: Chifu, Irina, et al.
Publicado: (2020)

Colorectal Cancer: The Contribution of CXCL12 and Its Receptors CXCR4 and CXCR7
por: Goïta, Aïssata Aimée, et al.
Publicado: (2022)

Molecular insights into intrinsic transducer-coupling bias in the CXCR4-CXCR7 system
por: Sarma, Parishmita, et al.
Publicado: (2023)

Genetic Polymorphism and Expression of CXCR4 in Breast Cancer
por: Okuyama Kishima, Marina, et al.
Publicado: (2015)

Calcineurin/CXCR4 in T-ALL
por: Passaro, Diana, et al.
Publicado: (2015)

Advances in CXCR7 Modulators
por: Lounsbury, Nicole
Publicado: (2020)

Near-infrared molecular imaging of tumors via chemokine receptors CXCR4 and CXCR7
por: Meincke, Manuela, et al.
Publicado: (2011)

Involvement of the CXCR7/CXCR4/CXCL12 Axis in the Malignant Progression of Human Neuroblastoma
por: Liberman, Julie, et al.
Publicado: (2012)

CXCR1/CXCR2 Antagonism Is Effective in Pulmonary Defense against Klebsiella pneumoniae Infection
por: Wei, Jing, et al.
Publicado: (2013)

CXCR4 and CXCR7 transduce through mTOR in human renal cancer cells
por: Ieranò, C, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_g747v5piejb4k98l3f911ir3as