OPA1 deficiency accelerates hippocampal synaptic remodelling and age-related deficits in learning and memory

A healthy mitochondrial network is essential for the maintenance of neuronal synaptic integrity. Mitochondrial and metabolic dysfunction contributes to the pathogenesis of many neurodegenerative diseases including dementia. OPA1 is the master regulator of mitochondrial fusion and fission and is like...

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Detalles Bibliográficos
Autores principales: Bevan, Ryan J, Williams, Pete A, Waters, Caroline T, Thirgood, Rebecca, Mui, Amanda, Seto, Sharon, Good, Mark, Morgan, James E, Votruba, Marcela, Erchova, Irina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7566495/
https://www.ncbi.nlm.nih.gov/pubmed/33094281
http://dx.doi.org/10.1093/braincomms/fcaa101

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7566495/
https://www.ncbi.nlm.nih.gov/pubmed/33094281
http://dx.doi.org/10.1093/braincomms/fcaa101

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