Principles of mRNA control by human PUM proteins elucidated from multimodal experiments and integrative data analysis

The human PUF-family proteins, PUM1 and PUM2, posttranscriptionally regulate gene expression by binding to a PUM recognition element (PRE) in the 3′-UTR of target mRNAs. Hundreds of PUM1/2 targets have been identified from changes in steady-state RNA levels; however, prior studies could not differen...

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Detalles Bibliográficos
Autores principales: Wolfe, Michael B., Schagat, Trista L., Paulsen, Michelle T., Magnuson, Brian, Ljungman, Mats, Park, Daeyoon, Zhang, Chi, Campbell, Zachary T., Goldstrohm, Aaron C., Freddolino, Peter L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7566576/
https://www.ncbi.nlm.nih.gov/pubmed/32753408
http://dx.doi.org/10.1261/rna.077362.120

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7566576/
https://www.ncbi.nlm.nih.gov/pubmed/32753408
http://dx.doi.org/10.1261/rna.077362.120

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