Osteocyte RANKL is required for cortical bone loss with age and is induced by senescence

In aging mice, osteoclast number increases in cortical bone but declines in trabecular bone, suggesting that different mechanisms underlie age-associated bone loss in these 2 compartments. Osteocytes produce the osteoclastogenic cytokine RANKL, encoded by Tnfsf11. Tnfsf11 mRNA increases in cortical...

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Detalles Bibliográficos
Autores principales: Kim, Ha-Neui, Xiong, Jinhu, MacLeod, Ryan S., Iyer, Srividhya, Fujiwara, Yuko, Cawley, Keisha M., Han, Li, He, Yonghan, Thostenson, Jeff D., Ferreira, Elisabeth, Jilka, Robert L., Zhou, Daohong, Almeida, Maria, O’Brien, Charles A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7566701/
https://www.ncbi.nlm.nih.gov/pubmed/32870816
http://dx.doi.org/10.1172/jci.insight.138815

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7566701/
https://www.ncbi.nlm.nih.gov/pubmed/32870816
http://dx.doi.org/10.1172/jci.insight.138815

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