Single hepatocytes show persistence and transcriptional inactivity of hepatitis B

There is no cure for the more than 270 million people chronically infected with HBV. Nucleos(t)ide analogs (NUCs), the mainstay of anti-HBV treatment, block HBV reverse transcription. NUCs do not eliminate the intranuclear covalently closed circular DNA (cccDNA), from which viral RNAs, including pre...

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Detalles Bibliográficos
Autores principales: Balagopal, Ashwin, Grudda, Tanner, Ribeiro, Ruy M., Saad, Yasmeen S., Hwang, Hyon S., Quinn, Jeffrey, Murphy, Michael, Ward, Kathleen, Sterling, Richard K., Zhang, Yang, Perelson, Alan S., Sulkowski, Mark S., Osburn, William O., Thio, Chloe L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7566712/
https://www.ncbi.nlm.nih.gov/pubmed/33004689
http://dx.doi.org/10.1172/jci.insight.140584

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7566712/
https://www.ncbi.nlm.nih.gov/pubmed/33004689
http://dx.doi.org/10.1172/jci.insight.140584

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