Selective inhibition of arginase-2 in endothelial cells but not proximal tubules reduces renal fibrosis

Fibrosis is the final common pathway in the pathophysiology of most forms of chronic kidney disease (CKD). As treatment of renal fibrosis still remains largely supportive, a refined understanding of the cellular and molecular mechanisms of kidney fibrosis and the development of novel compounds are u...

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Detalles Bibliográficos
Autores principales: Wetzel, Michael D., Stanley, Kristen, Wang, Wei Wei, Maity, Soumya, Madesh, Muniswamy, Reeves, W. Brian, Awad, Alaa S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7566719/
https://www.ncbi.nlm.nih.gov/pubmed/32956070
http://dx.doi.org/10.1172/jci.insight.142187

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7566719/
https://www.ncbi.nlm.nih.gov/pubmed/32956070
http://dx.doi.org/10.1172/jci.insight.142187

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