IL-1 induces mitochondrial translocation of IRAK2 to suppress oxidative metabolism in adipocytes

Chronic inflammation is a common feature of obesity with elevated cytokines such as Interleukin-1 (IL-1) in circulation and tissues. Here, we report an unconventional IL-1R-MyD88-IRAK2-PHB/OPA1 signaling axis that reprograms mitochondrial metabolism in adipocytes to exacerbate obesity. IL-1 induced...

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Detalles Bibliográficos
Autores principales: Zhou, Hao, Wang, Han, Yu, Minjia, Schugar, Rebecca C., Qian, Wen, Tang, Fangqiang, Liu, Weiwei, Yang, Hui, McDowell, Ruth E., Zhao, Junjie, Gao, Ji, Dongre, Ashok, Carman, Julie A., Yin, Mei, Drazba, Judith A., Dent, Robert, Hine, Christopher, Chen, Yeong-Renn, Smith, Jonathan D., Fox, Paul L., Brown, J. Mark, Li, Xiaoxia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7566776/
https://www.ncbi.nlm.nih.gov/pubmed/32778760
http://dx.doi.org/10.1038/s41590-020-0750-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7566776/
https://www.ncbi.nlm.nih.gov/pubmed/32778760
http://dx.doi.org/10.1038/s41590-020-0750-1

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