CTCF as a boundary factor for cohesin-mediated loop extrusion: evidence for a multi-step mechanism

Mammalian genome structure is closely linked to function. At the scale of kilobases to megabases, CTCF and cohesin organize the genome into chromatin loops. Mechanistically, cohesin is proposed to extrude chromatin loops bidirectionally until it encounters occupied CTCF DNA-binding sites. Curiously,...

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Detalles Bibliográficos
Autor principal: Hansen, Anders S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2020
Materias:
Article Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7566886/
https://www.ncbi.nlm.nih.gov/pubmed/32631111
http://dx.doi.org/10.1080/19491034.2020.1782024

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7566886/
https://www.ncbi.nlm.nih.gov/pubmed/32631111
http://dx.doi.org/10.1080/19491034.2020.1782024

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