The Histone Methyltransferase SETDB1 Modulates Survival of Spermatogonial Stem/Progenitor Cells Through NADPH Oxidase

SETDB1, a histone H3 lysine 9 (H3K9) methyltransferase, is crucial in meiosis and embryo development. This study aimed to investigate whether SETDB1 was associated with spermatogonial stem cells (SSC) homeostasis. We found that knockdown of Setdb1 impaired cell proliferation, led to an increase in r...

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Detalles Bibliográficos
Autores principales: Li, Xueliang, Chen, Xiaoxu, Liu, Yingdong, Zhang, Pengfei, Zheng, Yi, Zeng, Wenxian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Genetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7567028/
https://www.ncbi.nlm.nih.gov/pubmed/33133132
http://dx.doi.org/10.3389/fgene.2020.00997

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7567028/
https://www.ncbi.nlm.nih.gov/pubmed/33133132
http://dx.doi.org/10.3389/fgene.2020.00997

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