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Comparative MD simulations and advanced analytics based studies on wild-type and hot-spot mutant A59G HRas

The Ras family of proteins is known to play an important role in cellular signal transduction. The oncoprotein Ras is also found to be mutated in ~90% of the pancreatic cancers, of which G12V, G13V, A59G and Q61L are the known hot-spot mutants. These ubiquitous proteins fall in the family of G-prote...

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Detalles Bibliográficos
Autores principales: Sharma, Neeru, Sonavane, Uddhavesh, Joshi, Rajendra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7567374/
https://www.ncbi.nlm.nih.gov/pubmed/33064725
http://dx.doi.org/10.1371/journal.pone.0234836