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Comparative MD simulations and advanced analytics based studies on wild-type and hot-spot mutant A59G HRas
The Ras family of proteins is known to play an important role in cellular signal transduction. The oncoprotein Ras is also found to be mutated in ~90% of the pancreatic cancers, of which G12V, G13V, A59G and Q61L are the known hot-spot mutants. These ubiquitous proteins fall in the family of G-prote...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7567374/ https://www.ncbi.nlm.nih.gov/pubmed/33064725 http://dx.doi.org/10.1371/journal.pone.0234836 |