IL-17A both initiates, via IFNγ suppression, and limits the pulmonary type-2 immune response to nematode infection

Nippostrongylus brasiliensis is a well-defined model of type-2 immunity but the early lung-migrating phase is dominated by innate IL-17A production. In this study, we confirm previous observations that Il17a-KO mice infected with N. brasiliensis exhibit an impaired type-2 immune response. Transcript...

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Detalles Bibliográficos
Autores principales: Ajendra, Jesuthas, Chenery, Alistair L., Parkinson, James E., Chan, Brian H. K., Pearson, Stella, Colombo, Stefano A. P., Boon, Louis, Grencis, Richard K., Sutherland, Tara E., Allen, Judith E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7567645/
https://www.ncbi.nlm.nih.gov/pubmed/32636457
http://dx.doi.org/10.1038/s41385-020-0318-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7567645/
https://www.ncbi.nlm.nih.gov/pubmed/32636457
http://dx.doi.org/10.1038/s41385-020-0318-2

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