Toward structure-based drug design against the epidermal growth factor receptor (EGFR)

Most of the available crystal structures of epidermal growth factor receptor (EGFR) kinase domain, bound to drug inhibitors, originated from ligand-based drug design studies. Here, we used variations in 110 crystal structures to assemble eight distinct families highlighting the C-helix orientation i...

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Detalles Bibliográficos
Autores principales: Haddad, Yazan, Remes, Marek, Adam, Vojtech, Heger, Zbynek
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Ltd. 2020
Materias:
Feature
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7567673/
https://www.ncbi.nlm.nih.gov/pubmed/33075469
http://dx.doi.org/10.1016/j.drudis.2020.10.007

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7567673/
https://www.ncbi.nlm.nih.gov/pubmed/33075469
http://dx.doi.org/10.1016/j.drudis.2020.10.007

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