Dissecting the roles of GRK2 and GRK3 in μ-opioid receptor internalization and β-arrestin2 recruitment using CRISPR/Cas9-edited HEK293 cells

Most G protein-coupled receptors (GPCRs) recruit β-arrestins and internalize upon agonist stimulation. For the μ-opioid receptor (μ-OR), this process has been linked to development of opioid tolerance. GPCR kinases (GRKs), particularly GRK2 and GRK3, have been shown to be important for μ-OR recruitm...

Descripción completa

Detalles Bibliográficos
Autores principales: Møller, Thor C., Pedersen, Mie F., van Senten, Jeffrey R., Seiersen, Sofie D., Mathiesen, Jesper M., Bouvier, Michel, Bräuner-Osborne, Hans
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7567791/
https://www.ncbi.nlm.nih.gov/pubmed/33060647
http://dx.doi.org/10.1038/s41598-020-73674-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7567791/
https://www.ncbi.nlm.nih.gov/pubmed/33060647
http://dx.doi.org/10.1038/s41598-020-73674-0

Ejemplares similares