Structure-based design and discovery of novel anti-tissue factor antibodies with cooperative double-point mutations, using interaction analysis

The generation of a wide range of candidate antibodies is important for the successful development of drugs that simultaneously satisfy multiple requirements. To find cooperative mutations and increase the diversity of mutants, an in silico double-point mutation approach, in which 3D models of all p...

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Detalles Bibliográficos
Autores principales: Chiba, Shuntaro, Tanabe, Aki, Nakakido, Makoto, Okuno, Yasushi, Tsumoto, Kouhei, Ohta, Masateru
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7567794/
https://www.ncbi.nlm.nih.gov/pubmed/33067496
http://dx.doi.org/10.1038/s41598-020-74545-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7567794/
https://www.ncbi.nlm.nih.gov/pubmed/33067496
http://dx.doi.org/10.1038/s41598-020-74545-4

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