Higher cytolytic score correlates with an immunosuppressive tumor microenvironment and reduced survival in glioblastoma

Cytolytic score (CYT), calculated from mRNA expression levels of granzyme and perforin, positively correlates with CD8+ T cell infiltration/activity in a variety of cancers. Unlike other cancers, higher CYT has been associated with worse prognosis in glioblastoma (GBM). To address this discrepancy,...

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Detalles Bibliográficos
Autores principales: Haddad, Alexander F., Chen, Jia-Shu, Oh, Taemin, Pereira, Matheus P., Joshi, Rushikesh S., Aghi, Manish K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7567862/
https://www.ncbi.nlm.nih.gov/pubmed/33067480
http://dx.doi.org/10.1038/s41598-020-73793-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7567862/
https://www.ncbi.nlm.nih.gov/pubmed/33067480
http://dx.doi.org/10.1038/s41598-020-73793-8

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