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Higher cytolytic score correlates with an immunosuppressive tumor microenvironment and reduced survival in glioblastoma
Cytolytic score (CYT), calculated from mRNA expression levels of granzyme and perforin, positively correlates with CD8+ T cell infiltration/activity in a variety of cancers. Unlike other cancers, higher CYT has been associated with worse prognosis in glioblastoma (GBM). To address this discrepancy,...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7567862/ https://www.ncbi.nlm.nih.gov/pubmed/33067480 http://dx.doi.org/10.1038/s41598-020-73793-8 |