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Modular and coordinated activity of AAA+ active sites in the double-ring ClpA unfoldase of the ClpAP protease
ClpA is a hexameric double-ring AAA+ unfoldase/translocase that functions with the ClpP peptidase to degrade proteins that are damaged or unneeded. How the 12 ATPase active sites of ClpA, 6 in the D1 ring and 6 in the D2 ring, work together to fuel ATP-dependent degradation is not understood. We use...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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National Academy of Sciences
2020
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7568338/ https://www.ncbi.nlm.nih.gov/pubmed/33020301 http://dx.doi.org/10.1073/pnas.2014407117 |