Multivalent interactions drive nucleosome binding and efficient chromatin deacetylation by SIRT6

The protein deacetylase SIRT6 maintains cellular homeostasis through multiple pathways that include the deacetylation of histone H3 and repression of transcription. Prior work suggests that SIRT6 is associated with chromatin and can substantially reduce global levels of H3 acetylation, but how SIRT6...

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Detalles Bibliográficos
Autores principales: Liu, Wallace H., Zheng, Jie, Feldman, Jessica L., Klein, Mark A., Kuznetsov, Vyacheslav I., Peterson, Craig L., Griffin, Patrick R., Denu, John M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7568541/
https://www.ncbi.nlm.nih.gov/pubmed/33067423
http://dx.doi.org/10.1038/s41467-020-19018-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7568541/
https://www.ncbi.nlm.nih.gov/pubmed/33067423
http://dx.doi.org/10.1038/s41467-020-19018-y

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