Cell composition and expansion strategy can reduce the beneficial effect of AKT-inhibition on functionality of CD8(+) T cells

AKT-inhibition is a promising approach to improve T cell therapies; however, its effect on CD4(+) T cells is insufficiently explored. Previously, we and others showed that AKT-inhibition during ex vivo CD8(+) T cell expansion facilitates the generation of polyfunctional T cells with stem cell memory...

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Detalles Bibliográficos
Autores principales: Mousset, Charlotte M., Hobo, Willemijn, de Ligt, Aafke, Baardman, Sjoerd, Schaap, Nicolaas P. M., Jansen, Joop H., van der Waart, Anniek B., Dolstra, Harry
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2020
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7568704/
https://www.ncbi.nlm.nih.gov/pubmed/32504246
http://dx.doi.org/10.1007/s00262-020-02612-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7568704/
https://www.ncbi.nlm.nih.gov/pubmed/32504246
http://dx.doi.org/10.1007/s00262-020-02612-w

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