Cargando…
Cell composition and expansion strategy can reduce the beneficial effect of AKT-inhibition on functionality of CD8(+) T cells
AKT-inhibition is a promising approach to improve T cell therapies; however, its effect on CD4(+) T cells is insufficiently explored. Previously, we and others showed that AKT-inhibition during ex vivo CD8(+) T cell expansion facilitates the generation of polyfunctional T cells with stem cell memory...
| Autores principales: | , , , , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Springer Berlin Heidelberg
2020
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7568704/ https://www.ncbi.nlm.nih.gov/pubmed/32504246 http://dx.doi.org/10.1007/s00262-020-02612-w |