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Amitriptyline interferes with autophagy-mediated clearance of protein aggregates via inhibiting autophagosome maturation in neuronal cells

Amitriptyline is a tricyclic antidepressant commonly prescribed for major depressive disorders, as well as depressive symptoms associated with various neurological disorders. A possible correlation between the use of tricyclic antidepressants and the occurrence of Parkinson’s disease has been report...

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Detalles Bibliográficos
Autores principales: Kwon, Yoonjung, Bang, Yeojin, Moon, Soung-Hee, Kim, Aeri, Choi, Hyun Jin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7568721/
https://www.ncbi.nlm.nih.gov/pubmed/33070168
http://dx.doi.org/10.1038/s41419-020-03085-6